Description
|
Catalog #
|
CAS #
|
Target
|
Size
|
Price ($)
|
KN-92
|
SMBC10030
|
176708-42-2
|
ACa2+/CaM kinase II inhibitor.
Useful as a negative control for
KN-93
|
1 mg
|
105
|
KN-62
|
SMBC10031
|
127191-97-3
|
A cell-permeable, reversible, and
selective inhibitor of CaM kinase
II (Ki = 900 nM for rat brain CaM
kinase II) that binds directly to
the calmodulin binding site of
the enzyme.
|
1 mg
|
96
|
Brc-abl Inhibitor
(3-(6)-(4-Trifluorom
ethoxy-phenylamino
)-pyrimidin-4-yl)-ben
zamide, GNF-2
|
SMBC10032
|
778270-11-4
|
A cell-permeable and reverisble
pyrimidine compound that binds
to the c-abl myristoyl binding
pocket and acts as an allosteric,
non-ATP-competitive inhibitor of
cellular Bcr-abl activity and
Bcr-abl-dependent cellular
functions. Exhibits potent and
selective antiproliferative activity
toward Bcr-abl-expressing cells
(IC50 = 138 nM, 194 nM, 268 nM
and 273 nM in Ba/F3.p210,
Ba/F3.p185Y253H, SUP-B15
and Ba/F3.p210E255V, and
K562, respectively).
|
5 mg
|
120
|
PD 158780
|
SMBC10033
|
171179-06-9
|
A potent, cell-permeable,
reversible, ATP-competitive
inhibitor of the EGFR tyrosine
kinase activity (IC50 = 8 pM).
Also inhibits
heregulin-stimulated
autophosphorylation in SK-BR-3
(IC50 = 49 nM) and MDA-MB-453
(IC50 = 52 nM) breast
carcinomas.
|
10 mg
|
135
|
VEGFR Tyrosine
Kinase Inhibitor V
|
SMBC10034
|
|
A cell-permeable, ATP-binding
pocket-targeting
N-cyclopropylnaphthamide
compound that acts as a potent
inhibitor against VEGFR1/2/3
(IC50 = 0.6 nM against VEGFR2),
c-FMS, RET, Lyn, and c-KIt, while
exhibiting much reduced activity
against 36 other commonly
studied kinases.
|
5 mg
|
155
|
JNK Inhibitor II
|
SMBC10035
|
129-56-6
|
A potent, cell-permeable,
selective, and reversible inhibitor
of c-Jun N-terminal kinase (JNK)
(IC50 = 40 nM for JNK-1 and
JNK-2 and 90 nM for JNK-3). The
inhibition is competitive with
respect to ATP. Exhibits over
300-fold greater selectivity for
JNK as compared to ERK1 and
p38-2 MAP kinases.
|
5 mg
|
50
|
JNK Inhibitor II
|
SMBC10035
|
129-56-6
|
A potent, cell-permeable,
selective, and reversible inhibitor
of c-Jun N-terminal kinase (JNK)
(IC50 = 40 nM for JNK-1 and
JNK-2 and 90 nM for JNK-3). The
inhibition is competitive with
respect to ATP. Exhibits over
300-fold greater selectivity for
JNK as compared to ERK1 and
p38-2 MAP kinases.
|
25 mg
|
170
|
WHI-P180,
Hydrochloride
|
SMBC10036
|
211555-08-7
|
A potent inhibitor of
lgE-mediated mast cell
responses to allergens in vitro
and in vivo. Also inhibits
cyclin-dependent kinase 2
(Cdk2; IC50 = 1 µM) by blocking
the ATP site.
|
500 μg
|
75
|
WHI-P180,
Hydrochloride
|
SMBC10036
|
211555-08-7
|
A potent inhibitor of
lgE-mediated mast cell
responses to allergens in vitro
and in vivo. Also inhibits
cyclin-dependent kinase 2
(Cdk2; IC50 = 1 µM) by blocking
the ATP site.
|
1 mg
|
125
|
cdk2/5 Inhibitor
|
SMBC10037
|
|
An aminopyrimidine derivative
that acts as a selective and
ATP-competitive inhibitor of
Cdk2/cyclin E and Cdk5/p25 (Ki
= 2 µM). Binds to the
ATP-binding pocket of Cdk2.
|
5 mg
|
95
|
SB 202474
4-Ethyl-2(p-
methoxyphenyl)-5-
(4′-pyridyl)-IH-
imidazole
|
SMBC10038
|
172747-50-1
|
A negative control for SB202190
and SB203580 in p38 MAP
kinase inhibition studies.
|
1 mg
|
110
|
MMP-2 Inhibitor II
(4-(4-(Methanesulfo
namido)phenoxy)ph
enylsulfonyl)methylo
xirane
|
SMBC10039
|
869577-51-5
|
An oxirane analog of SB-3CT,
pMS that acts as a selective,
active site-binding, irreversible
inhibitor of MMP-2 (Ki = 2.4 µM).
Although less potent, it exhibits
enhanced selectivity towards
MMP-2 (Ki = 45 and 379 µM for
MMP-1 and MMP-7, respectively)
than SB-3CT, pMS.
|
5 mg
|
145
|
PTP Inhibitor I
|
SMBC10040
|
2491-38-5
|
A potent, cell-permeable, and
covalent protein tyrosine
phosphatase (PTP) inhibitor.
Inhibits SHP-1 (ΔSH2), the
catalytic domain of the SH2
domain-containing phosphatase
SHP-1 (Ki = 43 µM), and PTPIB
(Ki = 42 µM).
|
10 mg
|
120
|
Bisindolylmaleimid
e I .HCl
|
SMBC10041
|
176504-36-2
|
A reversible and ATP-competitive
inhibitor of protein kinase C (Ki =
10 nM). May inhibit protein
kinase A at much higher
concentrations (Ki = 2 µM).
|
1 mg
|
95
|
K-252c
|
SMBC10042
|
85753-43-1
|
A cell-permeable, reversible, and
ATP-competitive inhibitor of
protein kinase C (IC50 = 2.45
µM) and protein kinase A (IC50 =
25.7 µM).
|
1 mg
|
95
|
Rho Kinase
Inhibitor
|
SMBC10043
|
|
A cell-permeable
isoquinolinesulfonamide
compound that acts as a highly
specific, reversible, potent, and
ATP-competitive inhibitor of
G-protein Rho-associated
kinase (ROCK; Ki = 1.6 nM).
|
1 mg
|
160
|
Rho Kinase
Inhibitor
|
SMBC10043
|
|
A cell-permeable
isoquinolinesulfonamide
compound that acts as a highly
specific, reversible, potent, and
ATP-competitive inhibitor of
G-protein Rho-associated
kinase (ROCK; Ki = 1.6 nM).
|
5 mg
|
350
|
