Description
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Catalog #
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CAS#
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Target
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Size
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Price ( $)
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2′,7′-Dichlorofluorescin
Diacetate
H2DCFDA, 2′,7′-
Dichlorodihydrofluorescein
Diacetate
|
SMBC1016
|
4091-99-0
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Cell-permeable fluorogenic
probe that is useful for the
detection of reactive oxygen
species (ROS) and nitric oxide
(•NO) and for the
determination of the degree of
overall oxidative stress.
|
100
mg
|
50
|
GSK-3 Inhibitor IX
BIO, (2′Z,3′E)-6-
Bromoindirubin-3′-oxime
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SMBC1017
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667463-62-9
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GSK-3α/β
A cell-permeable bis-indolo
(indirubin) compound that acts
as a highly potent, selective,
reversible, and ATP-
competitive inhibitor of GSK-
3α/β (IC50 = 5 nM).
|
1 mg
|
85
|
Lck Inhibitor
4-Amino-5-(4-phenoxyphenyl
)-7H-pyrrolo[3,2-d]pyrimidin-
7-yl-cyclopentane
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SMBC1018
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213743-31-8
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Lck64-509 Y³94
A cell-permeable
pyrrolopyrimidine compound
that acts as a potent,
reversible, selective, and
ATP-competitive inhibitor of
Lck (IC50 at 5 µM ATP = < 1
nM, 2 nM, 70 nM, 1.57 µM and
1.98 µM for lck64-509 Y394,
Lckcd pY394, Src, Kdr and
Tie-2, respectively; IC50 at 1
mM ATP = 16 µM, 66 nM, 126
nM, 420 nM and 5.18 µM for
Lck64-509 Y394, Blk, Fyn, Lyn
and Csk, respectively).
|
1 mg
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85
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PI 3-Kβ Inhibitor VI, TGX-221
(±)-7-Methyl-2-(morpholin-4-
yl)-9-(1-phenylaminoethyl)-
pyrido[1,2-a]-pyrimidin-4-
one
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SMBC1019
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663619-89-4
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A cell-permeable morpholino-
pyrimidinone compound that
acts as a reversible, ATP-
competitive, selective, and
highly potent inhibitor of PI 3-
Kβ (IC50 = 0.005, 0.1, 5, and
≥3.5 µM for -β, -δ, -α and -γ
isoforms, respectively) with
little activity against a panel of
15 commonly studied protein
kinases even at
concentrations as high as
10.0 µM.
|
1 mg
|
239
|
PRL-3 Inhibitor
1-(2-Bromobenzyloxy)-4-bro
mo-2-benzylidene rhodanine
|
SMBC1021
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893449-38-2
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A cell-permeable benzylidene
rhodanine compound that
potently inhibits hPRL-3 (IC50
= 900 nM), a member of the
regenerating liver family
tyrosine phosphatases.
Shown to reduce the
invasiveness of murine
melanoma B16F10 cells.
|
10 mg
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120
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Anthrax Lethal Factor
Protease Inhibitor III
5-(5-(2-Chloro-5-trifluoromet
hyl-phenyl)-furan-2-ylmethyle
ne)-4-oxo-2-thioxo-thiazolidin
-3-yl)-acetic acid, BI-11B3
|
SMBC1024
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259811-62-6
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A cell-permeable,
rhodanine-acetic acid analog
that chelates the active site
Zn2+ and acts as a potent
inhibitor of anthrax lethal factor
(LF) metalloproteinase (Ki =
32 nM). Has only a minimal
inhibitory effect on MMP-2 and
MMP-9.
|
5 mg
|
135
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VEGFR 2/3 Kinase Inhibitor
3-(Indole-3-yl)-4-(3,4,5-trimet
hoxyphenyl)-1H-pyrrole-2,5-d
ione, Vascular Endothelial
Growth Factor Receptor 2/3
Kinase Inhibitor
|
SMBC1025
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133052-90-1
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PKC
A highly selective, cell-
permeable, and reversible
protein kinase C (PKC)
inhibitor (Ki = 10 nM) that is
structurally similar to
staurosporine. Acts as a
competitive inhibitor for the
ATP-binding site of PKC.
Shows high selectivity for
PKCα-, βI-, βII-, γ-, δ-, and ε-
isozymes.
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1 mg
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Inquire
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Bisindolylmaleimide I
2-[1-(3-Dimethylaminopropyl
)-1H-indol-3-yl]-3-(1H-indol-3
-yl)-maleimide, GF 109203X,
Gö 6850
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SMBC1026
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133052-90-1
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PKC
A highly selective, cell-
permeable, and reversible
protein kinase C (PKC)
inhibitor (Ki = 10 nM) that is
structurally similar to
staurosporine. Acts as a
competitive inhibitor for the
ATP-binding site of PKC.
Shows high selectivity for
PKCα-, βI-, βII-, γ-, δ-, and ε-
isozymes.
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1 mg
|
105
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Indirubin-3′-monoxime
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SMBC1027
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160807-49-8
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Gsk-3β
A potent, reversible, and ATP-
compatible inhibitor of GSK-3β
(glycogen synthase kinase
3β), Cdk1 (cyclin-dependent
kinase1) and Cdk5 (IC50 = 22
nM, 180 nM, and 100 nM,
respectively). Inhibits the
proliferation of a large range of
cells by arresting them in the
G2/M phase of the cell cycle.
|
1 mg
|
109
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SB 203580
4-(4-Fluorophenyl)-2-(4-meth
ylsulfinylphenyl)-5-(4-pyridyl)
1H-imidazole
|
SMBC1029
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152121-47-6
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P38MAPK
A highly specific, potent, cell-
permeable, selective,
reversible, and ATP-
competitive inhibitor of p38
MAP kinase (IC50 = 34 nM in
vitro, 600 nM in cells). Does
not significantly inhibit the JNK
and p42 MAP kinase at 100
µM. Inhibits IL-1 and TNF-α
production from LPS-
stimulated human monocytes
and the human monocyte cell
line THP-1 (IC50 = 50-100 nM).
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1 mg
|
55
|
AG 1478
4-(3-Chloroanilino)-6,7-dime
thoxyquinazoline
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SMBC1030
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175178-82-2
|
epidermal growth factor
receptor kinase
A cell-permeable, reversible,
ATP-competitive, highly potent
and selective inhibitor of
epidermal growth factor
receptor kinase (IC50 = 3 nM)
versus HER2-neu (IC50 >100
µM) and platelet-derived
growth factor receptor kinase
(IC50 >100 µM).
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1 mg
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28
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AG 1478
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SMBC1030
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175178-82-2
|
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5 mg
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80
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PD 169316
4-(4-Fluorophenyl)-2-(4-nitro
phenyl)-5-(4-pyridyl)-1H-imid
azole
|
SMBC1031
|
152121-53
|
p38 MAP kinase
A potent, cell-permeable,
reversible, competitive, and
selective p38 MAP kinase
inhibitor (IC50 = 89 nM).
Inhibition of p38 MAP kinase
by PD 169316 blocks
apoptosis induced by trophic
factor withdrawal in
non-neuronal and neuronal
cell lines.
|
1 mg
|
70
|
PD 169316
4-(4-Fluorophenyl)-2-(4-nitro
phenyl)-5-(4-pyridyl)-1H-imid
azole
|
SMBC1031
|
152121-53
|
p38 MAP kinase
A potent, cell-permeable,
reversible, competitive, and
selective p38 MAP kinase
inhibitor (IC50 = 89 nM).
|
5 mg
|
250
|
7BIO,7-Bromoindirubin-oxime
(2′Z,3′E)-7-Bromoindirubin-3′-
oxime, Indirubin-3′-monoxime, 7-
Bromo
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SMBC1028
|
916440-85-2
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ATP-competitive inhibitor of Flt3
(IC50 = 340 nM) and a
caspase-independent,
non-apoptotic cell death
inducer (IC50 of cell survival
ranges from 6.0 µM to 22.0 µM).
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5 mg
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140
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1,3-PBITU, Dihydrobromide
|
SMBC10044
|
|
A cell-permeable, highly potent
human nitric oxide synthase
(NOS) inhibitor that exhibits
about 200-fold higher selectivity
for inducible NOS (Ki = 47 nM)
compared to endothelial NOS
(Ki = 9 µM).
|
50 mg
|
70
|
7-Nitroindazole, Sodium Salt
|
SMBC10045
|
|
Inhibitor of nitric oxide synthase
in brain tissue.
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25 mg
|
75
|
SQ 22536
|
SMBC10046
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17318-31-9
|
Cell-permeable adenylate
cyclase inhibitor. Blocks PTH-
stimulation of adenylate cyclase
(IC50 = 200 µM). Reduces
PGE2-induced inhibition of
O2·– production.
|
5 mg
|
95
|
TCPOBOP
|
SMBC10048
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76150-91-9
|
The most potent known
member of the
phenobarbital-like class of
cytochrome P450
(CYP)-inducing agents. Acts as
a tumor promoter of murine
hepatocarcinogenesis
|
25 mg
|
105
|
D-24851
|
SMBC10049
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204205-90-3
|
A cell-permeable, potent
anticancer agent that
destabilizes microtubules in
tumor cells as well as in a
cell-free system. Binds directly
to tubulin and inhibits
polymerization (IC50 = 300 nM).
|
1 mg
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140
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