Description
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Catalog #
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CAS#
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Target
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Size
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Price ( $)
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AG 957
4-Amino-N-(2,5-dihydroxybe
nzyl)methyl benzoate, NSC
654705
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SMBC1046
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|
A potent tyrosine kinase
inhibitor. Selectively blocks the
tyrosine kinase activity of
human p210bcr-abl (Ki = 750
nM) over p140c-abl (Ki = 10
µM). Also decreases
p210bcr-abl phosphorylation in
viable K562 cells at
concentrations and durations of
exposure that also inhibit cell
proliferation
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5 mg
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110
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NF 449
4,4′,4′′,4′′′-[Carbonyl-bis[imino-
5,1,3-benzenetriyl bis-
(carbonylimino)]]tetrakis-
(benzene-1,3-disulfonic Acid,
8Na)
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SMBC1047
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389142-38-5
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A potent Gsα-subunit-selective
G-protein antagonist.
Suppresses the rate of GTPγS
binding to Gsα-s-subunit (IC50
= 140 nM) but not to Giα-1-
subunit. Inhibits stimulation of
adenylate cyclase activity in S49
cyc- cells (which lack
endogenous Gsα-subunit) by
exogenously added Gsα-
subunit.
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10 mg
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150
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Protein Arginine
N-Methyltransferase Inhibitor
PRMT Inhibitor, AMI-1
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SMBC1048
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A cell-permeable, symmetrical
sulfonated urea compound that
acts as a potent, specific and
non-AdoMet
(S-adenosyl-L-methionine,
SAM)-competitive inhibitor of
protein arginine
N-methyltransferases (PRMTs;
IC50 = 8.81 µM for PRMT1 and
3.03 for yeast-RMT1p) with
minimal effect on lysine
methyltransferases. Inhibits
nuclear receptor reporter gene
activation in MCF-7 cells, and
HIV-1 RT polymerase (IC50 = 5
µM).
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5 mg
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95
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GRAMICIDINE-A,High Purity,
Bacillus brevis
gA
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SMBC1050
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11029-61-1
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Naturally-occurring ion
channel-forming
pentadecapeptide. The
association of two gA peptides
causes the formation of a
monovalent cation-selective ion
channel. Causes K+/H+
exchange in mitochondria in a
non-voltage dependent
manner. Causes red blood cell
lysis at 0.5-1.0 µg/ml.
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25 mg
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220
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WY14643
[4-Chloro-6-(2,3-xylidino)-2-p
yrimidinylthio]acetic Acid
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SMBC1051
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50892-23-4
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One of the most potent
peroxisome proliferator-
activated receptor α (PPARα)
ligands. Inhibits TNF-α induced
expression of VCAM-1 in
endothelial cells. A
hepatocarcinogen and tumor
promoter. Also acts as a potent
anti-hypercholesterolemic
agent.
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50 mg
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105
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Guanosine 3′,5′-cyclic
Monophosphorothioate, 8-
Bromo-, Rp-Isomer, Sodium
Salt
Rp-8-Br-cGMPS, Na
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SMBC1052
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A potent, cell-permeable, and
metabolically stable inhibitor of
protein kinase G (PKG; Ki = 4
µM). Acts as a cyclic
nucleotide-gated channel
agonist (EC50 = 173.5 µM).
Significantly more lipophilic and
membrane-permeable than
cGMP or Rp-cGMPS.
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5 umol
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425
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ALSTERPAULLONE,
9-Nitro-7,12-dihydroindolo[3,2
-d][1]benzazepin-6(5H)-one,
9-Nitropaullone, NSC 705701
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SMBC1053
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237430-03-4
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A cell-permeable, potent,
reversible, and ATP competitive
inhibitor of GSK-3β (IC50 = 4
nM) and Cdk1/cyclin B (IC50 =
35 nM). Displays remarkable in
vitro antitumor activity. .
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1 mg
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56
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ALSTERPAULLONE,
9-Nitro-7,12-dihydroindolo[3,2
-d][1]benzazepin-6(5H)-one,
9-Nitropaullone, NSC 705701
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SMBC1053
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237430-03-4
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A cell-permeable, potent,
reversible, and ATP competitive
inhibitor of GSK-3β (IC50 = 4
nM) and Cdk1/cyclin B (IC50 =
35 nM). Displays remarkable in
vitro antitumor activity. .
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5 mg
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255
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GENISTEIN
Genistein, 7-O-β-D-
Glucopyranoside
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SMBC1054
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529-59-9
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An isoflavone glycoside found
in soy-based food products.
This is an inactive analog of the
PTK inhibitor Genistein and can
be used as a negative control
for Genistein.
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5 mg
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35
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AG 1433
2-(3,4-Dihydroxyphenyl)-6,7-
dimethylquinoxaline, HCl, SU
1433
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SMBC1055
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168836-03-1
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A potent, cell-permeable,
reversible, and specific inhibitor
of the PDGF-β receptor kinase
(IC50 = 5.0 µM) and of KDR/Flk-
1/VEGF Receptor 2 (IC50 = 9.3
µM). Also acts as an
angiogenesis inhibitor
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5 mg
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105
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AKT INHIBITOR
1L6-Hydroxymethyl-chiro-inosi
tol-2-(R)-2-O-methyl-3-O-oct
adecyl-sn-glycerocarbonate
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SMBC1058
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A cell permeable, reversible,
and substrate competitive
phosphatidylinositol ether
analog that potently and
selectively inhibits Akt (PKB)
(IC50 of 5.0 µM). Moderately
inhibits PI 3-K activity (IC50 =
83.0 µM).
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1 mg
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115
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PIFITHRIN A
2-(2-Imino-4,5,6,7-tetrahydrob
enzothiazol-3-yl)-1-p-tolyleth
anone, HBr
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SMBC1059
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63208-82-2
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A cell-permeable chemical
inhibitor of p53. Reversibly
inhibits p53-dependent
transactivation of
p53-responsive genes and
reversibly blocks p53-mediated
apoptosis. Inhibits
p53-dependent growth arrest of
human diploid fibroblasts in
response to DNA damage but
has no effect on p53-deficient
fibroblasts.
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10 mg
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120
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SB 202190
4-(4-Fluorophenyl)-2-(4-hydro
xyphenyl)-5-(4-pyridyl)1H-imi
dazole, FHPI
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SMBC1060
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152121-30-7
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A potent, reversible,
competitive, and cell-
permeable inhibitor of p38 MAP
kinase. Inhibits p38
phosphorylation of myelin basic
protein (MBP) with no effect on
the activity of the ERK or JNK
MAP kinase subgroups. Also
inhibits the kinase activity of
p38β (Ki = 16 nM; IC50 = 350
nM) and p38 phosphorylation of
activating transcription factor 2
(ATF-2; IC50 = 280 nM).
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5 mg
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65
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SB 202190
4-(4-Fluorophenyl)-2-(4-
hydroxyphenyl)-5-(4-pyridyl)
1H-imidazole, FHPI
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SMBC1060
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152121-30-7
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A potent, reversible,
competitive, and
cell-permeable inhibitor of p38
MAP kinase.
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10 mg
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110
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GO 6983
2-[1-(3-Dimethylaminopropyl)-
5-methoxyindol-3-yl]-3-(1H-in
dol-3-yl) maleimide, Go 6983
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SMBC1064
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133053-19-7
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A potent, cell-permeable,
reversible, and ATP-competitive
inhibitor of protein kinase C
(PKC) that inhibits several PKC
isozymes (IC50 = 7 nM for
PKCα and PKCβ; 6 nM for
PKCγ; 10 nM for PKCδ; and 60
nM for PKCζ).
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500 μg
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95
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PD153035
AG 1517,
4-[(3-Bromophenyl)amino]-6,
7-dimethoxyquinazoline, SU
5271, Compound 32
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SMBC1065
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153436-54-5
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An extremely potent,
cell-permeamble, reversible,
ATP-competitive and specific
inhibitor of the tyrosine kinase
activity of the epidermal growth
factor receptor (EGFR; IC50 =
25 pM; Ki = 6 pM).
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1 mg
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95
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Tpl2 Kinase Inhibitor
4-(3-Chloro-4-fluorophenylam
ino)-6-(pyridin-3-yl-methylami
no)-3-cyano-[1,7]-naphthyridi
ne
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SMBC100090
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871307-18-5
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A cell-permeable naphthyridine
compound that acts as a
potent, reversible, and
ATP-competitive inhibitor of
Tpl2 kinase (IC50 = 50 nM).
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1 mg
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125
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TER14687
(±)-2-N,N-Dimethylaminome
thyl-1-indanone, HCl
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SMBC1115
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16931-84-3
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Blocks the association
between protein kinase Cθ-V1
and p59fyn in a yeast reporter
assay. Prevents normal
translocation of PKCθ in T cells.
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10 mg
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150
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Denbufylline
1,3-Di-n-butyl-7-(2′-oxopropyl)
xanthine
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SMBC1117
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57076-71-8
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A cell-permeable xanthine
derivative that acts as a
selective inhibitor of
phosphodiesterase IV (PDE IV;
Ki = ~ 1 µM). Possesses
bronchodilatory properties.
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5 mg
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115
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AGL 2043
Tyrphostin AGL 2043,
1,2-Dimethyl-6-(2-thienyl)-im
idazolo[5,4-g]quinoxaline
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SMBC1118
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22617-28-8
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A cell-permeable tricyclic
quinoxaline compound that
acts as a potent, selective, ATP-
competitive, and reversible
inhibitor of type III receptor
tyrosine kinases PDGFR (IC50
= 800 nM in 3T3 cells; 90 nM
against purified PDGFβ-
receptor), Flt3, and Kit (IC50 = 1-
3 µM).
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1 mg
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220
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Trans-2-[3-(4-tert-Butylpheny
l)-2-methyl-2-propenylidene]
malononitrile
(DCTB)
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SMBC10053
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300364-84-5
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Used as matrix for MALDI-MS
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1 g
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95
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Trans-2-[3-(4-tert-Butylpheny
l)-2-methyl-2-propenylidene]
malononitrile
(DCTB)
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SMBC10053
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300364-84-5
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Used as matrix for MALDI-MS
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3 g
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260
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