Description
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Catalog #
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CAS#
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Target
|
Size
|
Price ( $)
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FURA 2, Pentasodium Salt
1-[2-(5-Carboxyoxazol-2-yl)-6-
aminobenzofuran-5-oxy]-2-(2′-
amino-5′-methylphenoxy)-
ethane-N,N,N′,N′-tetraacetic
Acid, 5Na
|
SMBC1099
|
|
Most widely used
ratiometric calcium
indicator. Highly selective
for Ca2+, however, it does
bind other divalent and
trivalent cations. Useful
for fluorescence
microscopy.
|
1 mg
|
125
|
PD 168393
4-[(3-Bromophenyl)amino]-6-a
crylamidoquinazoline
|
SMBC1100
|
194423-15-9
|
A potent, cell-permeable,
irreversible,
ATP-competitive and
selective inhibitor of EGF
receptor (EGFR) tyrosine
kinase activity (IC50 = 700
pM).
|
1 mg
|
115
|
GO 6976
12-(2-Cyanoethyl)-6,7,12,13-te
t
rahydro-13-methyl-5-oxo-5H-in
dolo(2,3-a)pyrrolo(3,4-c)-carba
zole
|
SMBC1101
|
136194-77-9
|
A cell-permeable,
reversible, and ATP-
competitive inhibitor of
protein kinase C (PKC;
IC50 = 7.9 nM for rat
brain). Selectively inhibits
Ca2+-dependent PKC α-
isozyme (IC50 = 2.3 nM)
and PKCβI (IC50 = 6.2
nM).
|
500 μg
|
130
|
UCH-L3 Inhibitor
Ubiquitin Thiolesterase L3
Inhibitor,
4,5,6,7-Tetrachloroindan-1,3-d
ione
|
SMBC1102
|
30675-13-9
|
A 1,3-indanedione
compound that acts as a
selective and potent
inhibitor of UCH-L3 (IC50
= 0.6 µM) with ~125-fold
greater selectivity over
UCH-L1 (IC50 = 75 µM).
|
10 mg
|
100
|
NF-κB Activation Inhibitor II,
JSH-23
4-Methyl-N¹-(3-phenylpropyl)
benzene-1,2-diamine
|
SMBC1103
|
749886-87-1
|
A cell-permeable diamino
compound that selectively
blocks nuclear
translocation of NF-κB
p65 and its transcription
activity (IC50 = 7.1 µM in a
NF-κB reporter assay
using RAW 264.7) without
affecting IκB degradation.
|
5 mg
|
120
|
PD 150606
3-(4-Iodophenyl)-2-mercapto-(
Z)-2-propenoic Acid
|
SMBC1104
|
426821-41-2
|
A cell-permeable,
non-competitive, selective
non-peptide calpain
inhibitor [Ki = 210 nM for
calpain-1and 370 nM for
calpain-2 directed
towards the calcium
binding sites of calpain.
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5 mg
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100
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Necrostatin-5
3-p-methoxyphenyl-5,6-tetram
e
thylenothieno[2,3-d]pyrimidin-
4
-one-2-mercaptoethylcyanide,
2-[[3,4,5,6,7,8-hexahydro-3-(4-
methoxyphenyl)-4-oxo[1]benzo
thieno[2,3-d]pyrimidin-2-yl]thio]
-acetonitrile
|
SMBC1105
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337349-54-9
|
Necrostatin-5 is an
inhibitor of necroptosis
(non-apoptotic cell death
pathway) by indirect
inhibition of RIP1 kinase.
Necroptosis is defined as
alternative active cell
death pathway:
Death-Domain Receptor
(DRs, e.g. Fas/TNFR)
mediated and
caspase-inhibitor
insensitive with specific
morphology (nuclear
condensation, organelle
swelling, loss of plasma
membrane integrity).
|
25 mg
|
190
|
GSK-3β Inhibitor I
TDZD-8, 4-Benzyl-2-methyl-
1,2,4-thiadiazolidine-3,5-dione
|
SMBC1106
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327036-89-5
|
A thiadiazolidinone
(TDZD) analog that acts
as a highly selective, non-
ATP competitive inhibitor
of GSK-3β (IC50 = 2 µM).
Inhibits Flt-3 and PKC
activities (IC50 = 673 nM
and 1.4-5.5 µM,
respectively)
|
5 mg
|
80
|
Phosphodiesterase V
Inhibitor II
PDE V Inhibitor II
|
SMBC1107
|
|
A cell-permeable
tetrahydro-β-carboline-
hydantoin compound that
acts as a potent and
highly selective
phosphodiesterase V
inhibitor (IC50 = 5 nM for
bovine aorta PDE V; IC50
> 10 µM for human
recombinant PDE I & III,
and for bovine aorta PDE
II & IV].
|
5 mg
|
100
|
FTI-276 trifluoroacetate salt
N-[4-[2-(R)-Amino-3-mercapto
propyl]amino-2-phenylbenzoyl]
methionine trifluoroacetate
salt
|
SMBC1108
|
170006-72-1
(free base)
|
FTI-276 is a highly potent
RasCAAX
peptidomimetic. FTI-276
antagonizes both H and
K-Ras oncogenic
signaling. It is an inhibitor
of farnesyltransferase
(Ftase) in vitro with an
IC50 of 500 pM and is an
anti-cancer agent.
|
5 mg
|
390
|
RRD-251 hydrochloride
2-(2,4-Dichlorobenzyl)-2-thiop
seudourea hydrochloride,
Rb/Raf-1 disruptor 251
hydrochloride,
S-(2,4-Dichlorobenzyl)-isothio
uronium hydrochloride,
(2,4-Dichlorophenyl)carbamim
idothioic acid methyl ester
hydrochloride
|
SMBC1109
|
72214-67-6
|
RRD-251 hydrochloride is
a reversible, potent, and
selective disruptor of
Rb/Raf-1 interaction. The
retinoblastoma tumor
suppressor protein (Rb)
controls the G1-S
boundary by repressing
the transcriptional activity
of the E2F family of
transcription factors.
|
25 mg
|
110
|
RNA Polymerase III Inhibitor
ML-60218,
N-[1-(3-(5-Chloro-3-methylben
z
o[b]thiophen-2-yl-1-methyl-1H-
pyrazol-5-yl)]-2-chlorobenzene
sulfonamide
|
SMBC1110
|
577784-91-9
|
A cell-permeable
indazolo-sulfonamide
compound that displays
broad-spectrum inhibitory
activity against RNA
Polymerase III (IC50 = 27
and 32 µM for human and
S. cerevisiae RNA Pol III,
respectively).
|
10 mg
|
230
|
GSK-3 Inhibitor X
BIO-Acetoxime, (2′Z,3′E)-6-
Bromoindirubin-3′-acetoxime
|
SMBC1111
|
740841-15-0
|
An acetoxime analog of
BIO, GSK-3 Inhibitor IX
that exhibits greater
selectivity for GSK-3α/β
(IC50 = 10 nM) over
Cdk5/p25, Cdk2/A and
Cdk1/B (IC50 = 2.4 µM,
4.3 µM and 63 µM,
respectively).
|
1 mg
|
95
|
PTP Inhibitor III
α-Bromo-4-(carboxymethoxy)
acetophenone, 4-
(Carboxymethoxy)phenacyl Br,
Protein Tyrosine
Phosphatase Inhibitor III
|
SMBC1112
|
29936-81-0
|
A potent, cell-permeable,
and covalent protein
tyrosine phosphatase
(PTP) inhibitor. Binds to
SHP-1 (ΔSH2), the
catalytic domain of the
SH2 domain-containing
phosphatase SHP-1
|
10 mg
|
130
|
Wnt Agonist
2-Amino-4-(3,4-(methylenedio
x
y)benzylamino)-6-(3-methoxyp
henyl)pyrimidine, Wnt
Pathway Activator I
|
SMBC1113
|
853220-52-7
|
A cell-permeable
pyrimidine compound that
acts as a potent and
selective activator of Wnt
signaling without
inhibiting the activity of
GSK-3β (IC50 > 60 µM).
|
5 mg
|
155
|
AGL 2263
|
SMBC1114
|
638213-98-6
|
A cell-permeable
benzoxazolone-containing
bioisostere of tyrphostin
AG 538 (Cat. No.
SMBC1041) that acts as a
potent,
substrate-competitive, but
not ATP-competitive,
inhibitor of insulin
receptor (IR) and
insulin-like growth
factor-1 receptor (IGF-1R).
|
1 mg
|
60
|
AGL 2263
|
SMBC1114
|
638213-98-6
|
|
5 mg
|
165
|
N-(4-Hydroxyphenylpropanoyl)
spermine. 3 HCl
|
SMBC1119
|
130631-59-3
|
Potent glutamate
antagonist
Wasp toxin analog. More
potent than PhTX-343 at
locust NMJ. Antagonist of
the quisqualate-sensitive
L-glutamate receptor
(quis-GluR) of locust
muscle
|
250 µg
|
115
|
ENMD 547
|
SMBC1120
|
644961-61-5
|
PAR-2 Antagonist.
A selective PAR-2
antagonist. Dose
dependently inhibits
calcium signaling in
Lewis lung carcinoma
cells stimulated with a
soluble peptide PAR-2
agonist or trypsin, but not
with a soluble PAR-1
agonist. Does not inhibit
platelet aggregation
stimulated
|
20 mg
|
125
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Trans-2-[3-(4-tert-Butylphenyl)-
2-methyl-2-propenylidene]mal
ononitrile (DCTB)
|
SMBC1121
|
300364-84-5
|
Matrix substance for
MALDI-MS
|
1 g
|
115
|
JAK Inhibitor I
|
SMBC10014
|
457081-03-7
|
JAK PTK Inhibitor
Janus protein tyrosine
kinases (JAKs). Displays
potent inhibitory activity
against JAK1 (IC50 = 15
nM for murine JAK1),
JAK2 (IC50 = 1 nM), JAK3
(Ki = 5 nM), and Tyk2
(IC50 = 1 nM).
|
500 μg
|
95
|
